Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
58203 | Catalysis Today | 2007 | 6 Pages |
Abstract
A continuous micro-structured reactor equipped with a perforated (5 μm) membrane is used for the investigation of the gas–liquid–solid asymmetric hydrogenation of ethylpyruvate on a Pt/γ-Al2O3 catalyst modified with chiral inductors under high hydrogen pressure (45 bar). Up to eight chiral inductors have been evaluated, the best enantioselectivity (63%) being obtained with cinchonidine. The very low reaction volume (100 μl) offers short operating time. Solvent effect, deactivation studies and the effect of modifier leaching are also reported.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Radwan Abdallah, Bruno Fumey, Valérie Meille, Claude de Bellefon,