Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5821603 | Antiviral Research | 2016 | 9 Pages |
Abstract
Post-exposure treatment of MNV-infected mice with 2CMC was efficient up to 2 days after infection, preventing norovirus-induced diarrhea, delaying and reducing MNV shedding in stool of treated mice. Rehydration of 2CMC-treated animals did not result in a further improvement of the disease evolution compared to antiviral treatment only. The presence of MNV antigens and inflammation in the small intestine of infected mice inversely correlated with the effectiveness of delayed antiviral treatment. Anti-MNV IgGs were detected in re-challenged mice 10 weeks after the first contact, these protected the mice from re-infection. We here demonstrate the benefit of antiviral treatment in ongoing norovirus infections.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Joana Rocha-Pereira, Abimbola O. Kolawole, Eric Verbeken, Christiane E. Wobus, Johan Neyts,