| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5821693 | Antiviral Research | 2016 | 47 Pages |
Abstract
The disease outbreak caused by Middle East respiratory syndrome coronavirus (MERS-CoV) is still ongoing in the Middle East. Over 1700 people have been infected since it was first reported in September 2012. Despite great efforts, licensed vaccines or therapeutics against MERS-CoV remain unavailable. The MERS-CoV spike (S) protein is an important viral antigen known to mediate host-receptor binding and virus entry, as well as induce robust humoral and cell-mediated responses in humans during infection. In this review, we highlight the importance of the S protein in the MERS-CoV life cycle, summarize recent advances in the development of vaccines and therapeutics based on the S protein, and discuss strategies that can be explored to develop new medical countermeasures against MERS-CoV.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Qihui Wang, Gary Wong, Guangwen Lu, Jinghua Yan, George F. Gao,