| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5821762 | Antiviral Research | 2016 | 8 Pages |
Abstract
We have created a novel quaternary ammonium silane, K21 through sol-gel chemistry, using an ethoxylated version of an organosilane quaternary ammonium compound and TetraEthyl Ortho Silicate (TEOS) as precursors. Previous studies using the precursor molecule quaternary ammonium compounds (QACs) and a methacryloxy version of K21, primarily designed for use in dental healthcare, have shown inhibited growth properties against several types of gram-positive and gram-negative bacteria including Escherichia coli, Streptococcus mutans, Actinomyces naeslundii and Candida albicans etc. Here we tested the effect of K21 on HSV-1, HHV-6A and HHV-7 in in vitro cell culture infection models. Our results show growth inhibitory effect of K21 on HSV-1, HHV-6A and HHV-7 infection.
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Authors
Nitish Gulve, Kirk Kimmerling, Allen D. Johnston, Gerhard R. Krueger, Dharam V. Ablashi, Bhupesh K. Prusty,