Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5821822 | Antiviral Research | 2015 | 8 Pages |
Abstract
HIV-1 Vif protein is one of the most crucial accessory proteins for viral replication. It efficiently counteracts the important host restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G, A3G) which is lethal to HIV-1 by causing G to A mutation of viral genome. Vif protein mediates degradation of APOBEC3G via the complicated protein-protein interactions of Vif, APOBEC3G, Elongin C/B and Cullin 5. The importance of Vif-APOBEC3G complex makes it a good potential target to develop new therapeutics of HIV-1. We identified a potent HIV-1 replication inhibitor (ZBMA-1, IC50 = 1.01 μM) that efficiently protected APOBEC3G protein by targeting Vif-APOBEC3G complex. The co-immunoprecipitation and docking studies indicated that compound ZBMA-1 affected the binding of Elongin C with Vif protein.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Shaoyang Zhang, Limei Zhong, Bing Chen, Ting Pan, Xue Zhang, Liting Liang, Qianwen Li, Ziying Zhang, Hui Chen, Jie Zhou, Haihua Luo, Hui Zhang, Chuan Bai,