Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5821829 | Antiviral Research | 2015 | 9 Pages |
â¢New steroidal pregnenolone derivatives substituted at C-16 were synthesized.â¢Several derivatives showed an in vitro inhibitory effect on HSV-1.â¢Inhibition of both wild type and ACV-resistant strains was observed.â¢The compounds seem to interfere with the late steps of the viral cycle.
The conventional therapy for the management of Herpes Simplex Virus Type 1 (HSV-1) infections mainly comprises acyclovir (ACV) and other nucleoside analogues. A common outcome of this treatment is the emergence of resistant viral strains, principally when immunosuppressed patients are involved. Thus, the development of new antiherpetic compounds remains as a central challenge. In this work we describe the synthesis and the in vitro antiherpetic activity of a new family of steroidal compounds derived from the endogenous hormone pregnenolone. Some of these derivatives showed a remarkable inhibitory effect on HSV-1 spread both on wild type and ACV-resistant strains. The results also show that these compounds seem to interfere with the late steps of the viral cycle.