Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5822159 | Antiviral Research | 2014 | 10 Pages |
Abstract
This approach proved to be a fast and efficient screening method for FBDD target validation and discovery of starting hits for the development of higher affinity molecules that bind to novel allosteric sites.
Keywords
Helicaseadenosine 5′-(β,γ-imido) triphosphateNS3 helicaseFBDDAdoHcyS-adenosyl-l-homocysteineAMPPNPMTaseDENVSPAHCsAdoMetITCIC50DTTFBSHTSTSAnuclear magnetic resonanceS-adenosyl-L-methioninestandard deviationScintillation proximity assayNMRSurface plasmon resonanceSPRdithiothreitolMass spectrometryhigh-throughput screeningAntiviral screeningFragment-based screeningMethyltransferaseMolecular weightDengue virusNon-structural proteinpolyethylene glycolPEGLigand efficiencyIsothermal titration calorimetryHELFragment-based drug discovery
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Bruno Coutard, Etienne Decroly, Changqing Li, Andrew Sharff, Julien Lescar, Gérard Bricogne, Karine Barral,