Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5822201 | Antiviral Research | 2014 | 11 Pages |
Abstract
Therapies to prevent or reverse endothelial dysfunction and vascular leak found in dengue hemorrhagic fever (DHF) have not been identified. In this review we summarize dengue viruses and the spectrum of human disease and highlight evidence of endothelial cell dysfunction in DHF based on studies in patients and mouse and tissue culture models. Evidence suggests that both virus antigen and host immune response, can cause endothelial cell dysfunction and weaken endothelial barrier integrity. We suggest possible therapeutic interventions and highlight how therapies targeting altered endothelial function might be evaluated in animal models and in patients with DHF.
Keywords
MMPDC-SIGNVCAM-1DHFDENVS1PSCIDCLEC5AICAM-1interferonIFNinterleukinDengue hemorrhagic feverDengue feverEndothelial cellsnonstructuralVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)intercellular adhesion molecule-1Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrinvascular cell adhesion molecule-1Vascular leakDengue virussevere combined immunodeficient
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Authors
Anon Srikiatkhachorn, James F. Kelley,