Article ID Journal Published Year Pages File Type
5822493 Antiviral Research 2013 8 Pages PDF
Abstract
► Potential HBV TDF-resistant sites were selected based on bioinformatics analysis. ► Replication capacity and resistance phenotype were analyzed in vitro and in vivo. ► Two HBV mutants (rtP177G and rtF249A) showed enhanced resistance to TDF. ► The resistant mechanisms are discussed based on the RTs structural comparison.
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Related Topics
Life Sciences Immunology and Microbiology Virology
Preview
The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir
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