| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5822497 | Antiviral Research | 2013 | 15 Pages |
Abstract
⺠A comparison between the L-Tag and E1 shows high similarity in the binding to the ORI. ⺠Polyoma- and papillomavirus helicases adopt a hexameric form to unwind the viral DNA. ⺠E6 and E7 share conserved motifs with the L-Tag for the inactivation of p53 and Rb. ⺠Compounds targeting the helicases of polyoma- and papillomavirus are presented.
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Authors
D. Topalis, G. Andrei, R. Snoeck,