Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5822498 | Antiviral Research | 2013 | 8 Pages |
Abstract
⺠P3 residues are not necessary for potent inhibition of WNV protease. ⺠Acetyl-KR-aldehyde has a IC50 of 170 nM against WNV protease. ⺠Acetyl-K-agmatine (without an aldehyde warhead) does not inhibit WNV protease. ⺠Small modifications of inhibitor structure can lead to major changes in the conformation of the WNV protease.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
CongBao Kang, Shovanlal Gayen, Weiling Wang, Rene Severin, Angela Shuyi Chen, Huichang Annie Lim, Cheng San Brian Chia, Andreas Schüller, Danny Ngoc Phouc Doan, Anders Poulsen, Jeffrey Hill, Subhash G. Vasudevan, Thomas H. Keller,