| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5822577 | Antiviral Research | 2012 | 8 Pages |
Abstract
⺠We observed in vitro infection with EV71 induced a biphasic activation of ERK. ⺠Inhibition of ERK activation and knockdown of MEK1 clearly impaired virus production. ⺠By contrast, silencing MEK2 expression did not such effect. ⺠Both MEK isoforms were activated and translocated to nucleus upon EV71 infection. ⺠We conclude that only MEK1-ERKs activation is necessary for the virus production.
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Authors
Bo Wang, Hao Zhang, Meng Zhu, Zhijun Luo, Yihong Peng,