| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5822582 | Antiviral Research | 2012 | 12 Pages |
Abstract
⺠Resistance mechanism of three main HCV NS3/4A mutants to TMC435 were investigated. ⺠R155K and D168A mutations break the intermolecular salt bridges network. ⺠A156V mutation disrupts the two substrate-like intermolecular hydrogen bonds. ⺠The three key mutations make NS3A change the induced-fit binding conformation.
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Authors
Weiwei Xue, Dabo Pan, Ying Yang, Huanxiang Liu, Xiaojun Yao,