Article ID Journal Published Year Pages File Type
5822649 Antiviral Research 2012 9 Pages PDF
Abstract
► A replicative plasmid harboring PCV2 Ori-rep was evaluated as a DNA vaccine vector. ► This plasmid was compared to a non-replicative PCV2-derived plasmid. ► These plasmids were used to vaccinate pigs against Pseudorabies virus infection. ► Pigs were more affected by PrV-infection with the replicative plasmid. ► This study shows an in vivo deleterious effect of PCV2 Ori-rep on PrV protection.
Keywords
Related Topics
Life Sciences Immunology and Microbiology Virology
Preview
The protective immune response against Pseudorabies virus induced by DNA vaccination is impaired if the plasmid harbors a functional Porcine circovirus type 2 rep and origin of replication
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