| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5822669 | Antiviral Research | 2012 | 9 Pages |
Abstract
⺠Hepatitis B virus (HBV) does not efficiently activate pattern recognition receptor (PRR)-mediated innate immune responses. ⺠HBV engages with multiple components of PRR signal transduction pathways. ⺠Activation of toll-like receptors (TLRs) and RIG-I-like receptors potently inhibits HBV replication. ⺠Interferons target multiple steps of the HBV life cycle. ⺠TLR7 agonists have demonstrated encouraging therapeutic efficacy in preclinical studies.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Jinhong Chang, Timothy M. Block, Ju-Tao Guo,