Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5822687 | Antiviral Research | 2012 | 10 Pages |
Abstract
⺠We need a therapeutic vaccine to control viral replication in chronic hepatitis B. ⺠The best antigens to include in the vaccine have not been identified. ⺠CD8+ T cell responses to HBV core antigens control replication in inactive healthy carriers. ⺠We could not detect CD8+ T cell responses to pre-S/S and P ORF antigens in inactive healthy carriers. ⺠pre-S/S and P ORF antigens may not be needed in a therapeutic vaccine for chronic hepatitis B.
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Authors
William G.H. Abbott, Peter Tsai, Howard A. Ross, Malakai 'Ofanoa, Alexander J. Trevarton, John Hornell, Stephen R. Munn, Edward J. Gane,