| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5822701 | Antiviral Research | 2012 | 8 Pages |
Abstract
⺠An in vitro strategy to predict the tissue permeation potential of microbicides is described. ⺠This strategy is based on solubility and permeability profiling of microbicides. ⺠Tenofovir exhibits the best permeation compared to darunavir, saquinavir and dapivirine. ⺠Dapivirine permeation can be enhanced by including excipients in HEC-based gels. ⺠The proposed biopharmaceutical profiling may reduce microbicide failure in vivo.
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Authors
Carolien Grammen, Patrick Augustijns, Joachim Brouwers,