| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5822718 | Antiviral Research | 2012 | 10 Pages |
Abstract
⺠Increased expression in oxidative stress-related genes (MT2A, HSPA6, GDF15, DDIT3). ⺠Inflammation-associated genes are up- (SERPINE1), and down-regulated (CXCL10). ⺠Regarding metabolic stress, EFV increases the expression of CYP1A1.
Keywords
NRTINNRTIEFVUPRΔΨmHAARTDNAEfavirenzROSDifferential gene expressionhighly active antiretroviral therapyendoplasmatic reticulumHepatotoxicityNon-nucleoside reverse transcriptase inhibitornucleoside reverse transcriptase inhibitorMitochondriaHIVStress responseUnfolded protein responseMitochondrial transmembrane potentialReactive oxygen species
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Authors
Leysa J. Gomez-Sucerquia, Ana Blas-Garcia, Miguel Marti-Cabrera, Juan V. Esplugues, Nadezda Apostolova,