| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5822749 | Antiviral Research | 2011 | 7 Pages |
Abstract
⺠Sulfation of Agaricus brasiliensis mycelial polysaccharide to obtain its sulfated derivative (MI-S). ⺠MI-S showed selectivity indices higher than 439, 208, and 562 for HSV-1 KOS, HSV-1 29R, and HSV-2 strain 333, respectively. ⺠MI-S presented multiple modes of anti-HSV action. ⺠MI-S inhibited HSV attachment, penetration, protein expression, and cell-to-cell spread. ⺠MI-S displayed synergistic antiviral effect with acyclovir.
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Authors
Francielle Tramontini Gomes de Sousa Cardozo, Carla MaÃsa Camelini, Alessandra Mascarello, Márcio José Rossi, Ricardo José Nunes, Célia Regina Monte Barardi, Margarida Matos de Mendonça, Cláudia Maria Oliveira Simões,