Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
582324 | Journal of Hazardous Materials | 2009 | 12 Pages |
Abstract
Previous epidemiological studies have indicated that ingested inorganic arsenic is strongly associated with a wide spectrum of internal cancers. Little is conducted, however, to assess health effects at long-term low dose exposures by linking biologically based mechanistic models and arsenic epidemiological data. We present an integrated approach by linking the Weibull dose-response function and a physiologically based pharmacokinetic (PBPK) model to estimate reference arsenic guideline. The proposed epidemiological data are based on an 8 years follow-up study of 10,138 residents in arseniasis-endemic areas in southwestern and northeastern Taiwan. The 0.01% and 1% excess lifetime cancer risk based point-of-departure analysis were adopted to quantify the internal cancer risks from arsenic in drinking water. Positive relationships between arsenic exposures and cumulative incidence ratios of bladder, lung, and urinary-related cancers were found using Weibull dose-response model r2 = 0.58-0.89). The result shows that the reference arsenic guideline is recommended to be 3.4 μg Lâ1 based on male bladder cancer with an excess risk of 10â4 for a 75-year lifetime exposure. The likelihood of reference arsenic guideline and excess lifetime cancer risk estimates range from 1.9-10.2 μg Lâ1 and 2.84 Ã 10â5 to 1.96 Ã 10â4, respectively, based on the drinking water uptake rates of 1.08-6.52 L dâ1. This study implicates that the Weibull model-based arsenic epidemiological and the PBPK framework can provide a scientific basis to quantify internal cancer risks from arsenic in drinking water and to further recommend the reference drinking water arsenic guideline.
Related Topics
Physical Sciences and Engineering
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Authors
Chung-Min Liao, Huan-Hsiang Shen, Chi-Ling Chen, Ling-I Hsu, Tzu-Ling Lin, Szu-Chieh Chen, Chien-Jen Chen,