Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5824567 | Clinical Therapeutics | 2016 | 13 Pages |
Abstract
Once-daily HYD exhibits linear, dose-proportional PK properties and is associated with a lower variability in plasma hydrocodone concentrations when compared with an immediate-release hydrocodone combination product. Notably, analgesia provided by HYD is sustained during the 24-hour dosing interval. ClinicalTrials.gov identifier: NCT01400139 (Study 4).
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Authors
Ram P. PhD, Alessandra MSHS, Warren PhD, Shau PhD, Ellie PhD, Salvatore V. MS, Stephen C. MD,