Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5824573 | Clinical Therapeutics | 2016 | 10 Pages |
Abstract
Cinacalcet was well tolerated and effective after administration of a single oral dose up to 100 mg and multiple doses of 50 mg of cinacalcet once daily for 7 days. Cinacalcet has nonlinear PK properties over a dose range of 25 to 100 mg after a single dose. PK profiles after multiple doses were similar to those after a single dose with no accumulation. Cinacalcet had similar PK and safety profiles between Chinese and Western HVs at the same dose levels.
Keywords
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Authors
Hongzhong MD, Hongyun PhD, Tao BSc, Ji PhD, Xia MD, Feng BSc, Pei MD,