Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5825228 | Clinical Therapeutics | 2014 | 11 Pages |
Abstract
This pooled analysis found that linagliptin was well tolerated and significantly improved hyperglycemia in a clinically challenging population of patients with long-standing T2DM (>10 years). Although T2DM is commonly associated with diminished β-cell function, the extent of glucose lowering was similar to that in linagliptin trials, which largely included patients in earlier stages of the disease. Thus, this observation supports the hypothesis that regulation of glucagon release from pancreatic α cells may be of particular relevance for improving hyperglycemia in patients with long-term T2DM (NCT01194830 and NCT01084005).
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Authors
Rosemarie MD, Richard MD, Uwe Dipl-Stat, Hans-Juergen MD, Maximilian MD,