Ceftazidime Dosage Recommendations in Burn Patients: From a Population Pharmacokinetic Approach to Clinical Practice via Monte Carlo Simulations

Age and serum creatinine level can be used at the bedside to determine the initial doses of ceftazidime. These Monte Carlo simulations highlight the need of a reappraisal of ceftazidime's use in burn patients. Doses between 3 and 16 g/d are proposed, taking into account the pathogens' MICs. However, for sepsis caused by a pathogen with an MIC ≥8 mg/L, an insufficient percentage of burn patients will reach the therapeutic target with the recommended dosages.