Effect of Organic Anion-Transporting Polypeptide 1B1 (OATP1B1) Polymorphism on the Single- and Multiple-Dose Pharmacokinetics of Enalapril in Healthy Chinese Adult Men

In this small population of healthy Chinese men, the OATP1B1*15 allele and T521C variant appeared to be an important determinant of the pharmacokinetics of enalapril. There were significant differences between the *15 carriers and noncarriers in enalapril's AUCss and enalaprilat's AUC0-24h, Cmax, and Rac. However, there were no significant differences in enalapril's AUC0-24, Cmax, or enalaprilat's AUCss, Cmaxss between the *15 carriers and noncarriers.