| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5825850 | Current Opinion in Pharmacology | 2016 | 6 Pages |
Abstract
Typical hallmarks of cancer include programmed cell death evasion, uncontrolled cell growth, invasion, and metastasis. Changes in intracellular Ca2+ levels can modulate signaling pathways that control a broad range of cellular events, including those important to tumorigenesis and cancer progression. Here we discuss how known molecular mediators of cellular Ca2+ homeostasis impact tumor dynamics and how deregulation of major oncogenes and tumor suppressors is tightly associated with Ca2+ signaling.
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Authors
Saverio Marchi, Paolo Pinton,