Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5825869 | Current Opinion in Pharmacology | 2016 | 9 Pages |
Abstract
Lipids are not only constituents of cellular membranes but also key signaling mediators, thus acting as 'bioactive lipids'. Among the prominent roles exerted by bioactive lipids are immune regulation, inflammation and maintenance of homeostasis. Accumulated evidence indicates the existence of a bidirectional relationship between immune and nervous systems, whereby inflammatory mediators can directly modulate emotions that, in turn, can strongly influence immune responses, thus affecting health. This review summarizes current knowledge on the ability of several families of bioactive lipids to regulate immunity and inflammation (through pro-inflammatory or anti-inflammatory effects), as well as to control emotions and mood-related manifestations, advocating these substances as an attractive interface between 'mind' and 'body', and as a potential target to treat inflammatory/immune-mediated mood disorders.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Valerio Chiurchiù, Mauro Maccarrone,