| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826217 | Current Opinion in Pharmacology | 2012 | 5 Pages |
Abstract
⺠In skeletal muscle diseases muscles undergo atrophy or wasting. ⺠The NAD-dependent protein deacetylase SIRT1 exerts pleiotropic beneficial effects. ⺠SIRT1 ameliorates muscle function during injury and aging. ⺠SIRT1 activity inhibits inflammatory processes, such as in muscular dystrophy. ⺠SIRT1 activity governs macrophage and satellite cells functions in the muscle.
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Authors
Joanne Tonkin, Francesc Villarroya, Pier Lorenzo Puri, Manlio Vinciguerra,