| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826329 | Current Opinion in Pharmacology | 2012 | 7 Pages |
Abstract
⺠Understanding neural immune communication may expose novel targets for analgesic development. ⺠Chemokines are upregulated in neuropathic animals; inhibition of their activity attenuates pain. ⺠CX3CL1/R1 mediates neuron-microglia communication; CX3CR1 null mice do not develop allodynia. ⺠CCL2/R2 mediates neuron-microglia-astrocyte communication; CCR2 antagonists are anti-hyperalgesic. ⺠Centrally penetrant CX3CR1/CCR2 antagonists constitute a novel approach to the treatment of pain.
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Authors
Elizabeth Amy Old, Marzia Malcangio,