| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826332 | Current Opinion in Pharmacology | 2012 | 5 Pages |
Abstract
⺠Multiple μ-opioid receptors (splice variants) are involved in the antinociception induced by μ-opioid receptor agonists. ⺠Atypical μ-opioid receptors (specific splice variants) may be involved in the distinct antinociceptive profile of discrete agonists. ⺠Atypical μ-opioid receptors may be involved in the lack of rewarding effect of some μ-opioid receptor agonists. ⺠μ-Opioid receptor agonists specific for atypical μ-opioid receptors may be effective against morphine-resistant interactive pain. ⺠Atypical μ-opioid receptors may be the target molecule to produce analgesics better than morphine.
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Authors
Hirokazu Mizoguchi, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada,