| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826343 | Current Opinion in Pharmacology | 2013 | 7 Pages |
Abstract
⺠Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is an anti-atherosclerotic molecule. ⺠Hypercholesterolemia leads to oxidative stress, uncoupling of eNOS and reduced eNOS activity. ⺠The resulting reduction in NO bioavailability promotes atherogenesis. ⺠Some compounds can prevent eNOS uncoupling and enhance eNOS activity at the same time. ⺠Such pharmacological approaches are of therapeutic interest.
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Authors
Huige Li, Ulrich Förstermann,