| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826363 | Current Opinion in Pharmacology | 2013 | 5 Pages |
Abstract
⺠The anti-atherosclerotic effect of statins is consequence of not only cholesterol lowering but also of pleiotropic effects. ⺠Pleiotropic effects result from the inhibition of small GTPases which mediate cell proliferation and vascular inflammation. ⺠GTPase inhibition also reduces oxidative stress and increases vascular NO formation. ⺠Statins also induce the transcription factor KLF-2, which mediates vascular quiescence.
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Authors
Andrea Babelova, Daniel G Sedding, Ralf P Brandes,