| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826393 | Current Opinion in Pharmacology | 2012 | 8 Pages |
Abstract
⺠Purinergic signaling in the gut is remarkably plastic and compartmentalized. ⺠Inflammation decreases purinergic neurovascular and neuromuscular transmission. ⺠Purine release from immune and epithelial cells is increased in colitis. ⺠P2X7 receptor and pannexin channel activation in colitis leads to neuronal loss. ⺠Inflammation-induced nociception involves spinal afferent P2X receptor activation.
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Authors
Jane A Roberts, Mark K Lukewich, Keith A Sharkey, John B Furness, Gary M Mawe, Alan E Lomax,