| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826397 | Current Opinion in Pharmacology | 2012 | 7 Pages |
Abstract
⺠MUC1 upregulated the expression of the cholesterol metabolic pathway. ⺠Tam inhibits ACAT, cholesterol biosynthesis and ChEH activity and stimulates ROS production in tumor cells. ⺠Tumor initiating cells expressed MUC1 and are dysregulated for cholesterol metabolism. ⺠MUC1, ACAT, and ChEH are druggable targets for breast cancer treatment.
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Authors
Marc Poirot, Sandrine Silvente-Poirot, Ralph R Weichselbaum,