| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826398 | Current Opinion in Pharmacology | 2012 | 6 Pages |
Abstract
⺠Dietary and plasma cholesterol levels are weakly associated with CRC development. ⺠Statin use is associated with a 10% reduction in all (unselected) CRC. ⺠Haplotypes of CYP7A1 (enzyme in bile acid production) are associated with CRC. ⺠Haplotypes of HMGCoA reductase influence CRC chemoprevention by Statins. ⺠Molecular features of CRC (SMAD4, KRAS) may predict sensitivity to Statins.
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Authors
Rutger J Jacobs, Philip W Voorneveld, Ludmilla L Kodach, James CH Hardwick,