Article ID Journal Published Year Pages File Type
5826400 Current Opinion in Pharmacology 2012 6 Pages PDF
Abstract
► N-Ras and K-Ras resistant to FTIs as a consequence of alternative geranylgeranylation. ► Minimal clinical activity of FTIs in phase I-III trials. ► RASGRP1/APTX-gene expression as predictor of response to tipifarnib in AML.
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