| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826401 | Current Opinion in Pharmacology | 2012 | 7 Pages |
Abstract
⺠Cholesterol biosynthesis is a highly conserved, from yeast to humans, metabolic pathway that is the essential for cell growth. ⺠Alterations in the cellular sterol pools have profound effects on endosomes trafficking. ⺠And also on the signaling activity of most cellular receptor systems in cancer cells. ⺠Specific targeting of sterol pathway enzymes or sterol binding proteins may be a powerful anticancer strategy. ⺠Especially given the absolute linearity and non-redundancy of the pathway.
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Authors
Andrey Gorin, Linara Gabitova, Igor Astsaturov,