| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826408 | Current Opinion in Pharmacology | 2012 | 9 Pages |
Abstract
⺠The RCC clear cell phenotype represents deregulated lipid and cholesterol synthesis. ⺠Obesity and mevalonate pathway activation play a role in RCC development. ⺠TRC8 degrades preSREBP1/2 and HMGCR to inhibit the mevalonate pathway. ⺠Two hereditary RCC genes, TRC8 and FLCN, inhibit cholesterol/lipid biosynthesis.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Harry A Drabkin, Robert M Gemmill,