| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826595 | Current Opinion in Pharmacology | 2007 | 7 Pages |
Abstract
γ-Glutamyltransferase, a key enzyme of GSH metabolism, can modulate crucial redox-sensitive functions, such as antioxidant/antitoxic defences and cellular proliferative/apoptotic balance, with potential implications in tumour progression and drug resistance. Recent studies have elucidated the mechanisms of GGT involvement in various pathological processes suggesting its potential role as therapeutic target and diagnostic/prognostic marker.
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Authors
Alfonso Pompella, Alessandro Corti, Aldo Paolicchi, Chiara Giommarelli, Franco Zunino,