| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5826713 | European Journal of Pharmacology | 2016 | 7 Pages |
Abstract
In summary, the application of lacosamide results in a significant decrease of the augmented spontaneous activity and responsiveness to cold of corneal sensory nerves from tear-deficient animals. Based on these promising results we speculate that lacosamide might be used to reduce the hyperexcitability of corneal cold receptors caused by prolonged ocular surface dryness due to hyposecretory or evaporative dry eye disease.
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Authors
Illés Kovács, Lóránt Dienes, Kristóf Perényi, Susana Quirce, Carolina Luna, Kamila Mizerska, M. Carmen Acosta, Carlos Belmonte, Juana Gallar,