Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5826729 | European Journal of Pharmacology | 2016 | 9 Pages |
Abstract
In clinical glaucoma, as well as in experimental models, the loss of retinal ganglion cells occurs by apoptosis. This final event is preceded by inflammatory responses involving the activation of innate and adaptive immunity, with retinal and optic nerve resident glial cells acting as major players. Here we review the current literature on the role of neuroinflammation in neurodegeneration, focusing on the inflammatory molecular mechanisms involved in the pathogenesis and progression of the optic neuropathy.
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Cellular and Molecular Neuroscience
Authors
Rossella Russo, Giuseppe Pasquale Varano, Annagrazia Adornetto, Carlo Nucci, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone,