Article ID Journal Published Year Pages File Type
5826797 European Journal of Pharmacology 2016 28 Pages PDF
Abstract
In summary, our study provided proteomic characteristics suggesting the decrease of antioxidant defense and structural disturbances in the brain mitochondria of apoE−/− mice as compared to healthy controls. In this setting, the use of metformin changed the expression of several proteins primarily involved in metabolic processes, the regulation of apoptosis and the structural maintenance of mitochondria, what could potentially restore their native functionalities.
Related Topics
Life Sciences Neuroscience Cellular and Molecular Neuroscience
Authors
, , , , , , , ,