| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5827218 | European Journal of Pharmacology | 2015 | 8 Pages |
Abstract
TCDD exposure caused significant body and heart weight loss, impairment of PO2%, and decrease of MBP and HR levels. Also, major ECG changes and prolongation of PR, QRS and QT durations were observed in TCDD-exposed rats. In biochemical analysis, TCDD significantly induced lipid peroxidation and reduced antioxidant activities. Moreover, our histopathological observations were in accordance with the biochemical results. According to the results, melatonin treatment significantly protected the subjects from TCDD-induced cardio-toxicity.
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Authors
Sarihan Mehmet Ediz, Parlakpinar Hakan, Ciftci Osman, Yilmaz Fethi, Sagir Mustafa, Yilmaz Omur, Ceker Gokhan,