Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B trans-repression pathway

Article ID	Journal	Published Year	Pages	File Type
5827445	European Journal of Pharmacology	2015	11 Pages	PDF

Keywords

sVCAM-1 HUVEC STZ LBD HFD Retinoid X receptor IκBα HOMA-IR PPARγ INS FBS FPG DMEM IL-6 ET-1 FINS RXR eNOS TNFα sICAM-1 PBS IKKα/β NF-κB MNT Dulbecco׳s modified Eagle׳s medium TZDs Angiotensin II PPRE streptozotocin inflammation endothelin-1 Endothelium insulin Fasting serum insulin interleukin-6 Diabetes Triglycerides tumor necrosis factor alpha Thiazolidinedione thiazolidinediones ligand binding domain Ang II rosiglitazone High fat diet fetal bovine serum Human umbilical vein endothelial cells endothelial nitric oxide synthase body mass index BMI Nuclear factor-kappa B Phosphate buffered saline phenylephrine Fasting plasma glucose Mannitol Insulin resistance Soluble intercellular adhesion molecule-1 sodium nitroprusside Nitric oxide SNP total cholesterol Peroxisome proliferator-activated receptor gamma Pioglitazone Glucose

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Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B trans-repression pathway

Authors

Ying Zhang, Ri-Xin Zhan, Jun-Qun Chen, Yan Gao, Li Chen, Ying Kong, Xiao-Juan Zhong, Mei-Qi Liu, Jia-Jia Chu, Guo-Qiang Yan, Teng Li, Ming He, Qi-Ren Huang,