Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5827508 | European Journal of Pharmacology | 2015 | 30 Pages |
Abstract
Early life social isolation stress (SIS), a well-known chronic stress paradigm, is contributed to a number of pathophysiological and neurochemical changes including depression and anxiety. The underlying mechanisms for these disorders in socially isolated animals have not been fully cleared. Previous studies have shown that N-Methyl-d-aspartate (NMDA) receptor function is changed by social isolation condition. It is now well recognized that NMDA receptor blockade can exhibit antidepressant and anxiolytic actions. In our study, postnatal day 21-25 mice were randomly housed for 4 weeks under either social condition (SC) or isolated condition (IC). Then, animals were subjected to different behavioral experiments to investigate whether blockade of NMDA receptor resulted in behavioral alterations in animals. Social isolation stress induced depressive and anxiety-like behaviors in IC animals in comparison with SC mice. Also, we applied subeffective doses of antagonists including ketamine (1Â mg/kg), MK-801 (0.05Â mg/kg), and magnesium sulfate (10Â mg/kg) to both SC and IC mice prior to behavioral experiments. Administration of a single dose of all mentioned drugs did not affect the SC mice but modulated the depressant effects of SIS on IC mice. Administration of NMDA receptor antagonists decreased the immobility time in the forced swimming test as well as an increase in grooming behavior in splash test. However, anxiety-like behaviors in IC animals remained unchanged in hole-board test and open field test after blockade of NMDA receptors. Taken together, our results showed the possible involvement of the NMDA receptors in the depressive, but not anxiety-like behaviors induced by SIS.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Arya Haj-Mirzaian, Shayan Amiri, Nastaran Kordjazy, Maryam Rahimi-Balaei, Arvin Haj-Mirzaian, Hassan Marzban, Azadeh Aminzadeh, Ahmad Reza Dehpour, Shahram Ejtemaei Mehr,