Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5827528 | European Journal of Pharmacology | 2015 | 9 Pages |
Abstract
The current study was aimed to investigate the gastroprotective effects of friedelin isolated from the hexane extract of leaves of Azima tetracantha. Ethanol-induced gastric ulcer model was used to investigate the gastroprotective effects of friedelin. Antioxidant enzymes, lipid peroxidation, nitric oxide, gastric vascular permeability, pro and anti-inflammatory cytokines and apoptosis level have been investigated. Ethanol caused severe gastric damage and friedelin pretreatment protected against its deleterious role. Antioxidant enzyme activities, anti-inflammatory cytokines, prostaglandin E2 (PGE2), constitutive nitric oxide synthase (cNOS) and mucus weight have been increased significantly. However, the vascular permeability, pro-inflammatory cytokines, inducible nitric oxide synthase (iNOS), caspase-3 and apoptosis level have significantly been decreased after friedelin ingestion. The present study has clearly demonstrated the anti-ulcer potential of friedelin, these findings suggested that friedelin could be a new useful natural gastroprotective tool against gastric ulcer.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Paulrayer Antonisamy, Veeramuthu Duraipandiyan, Adithan Aravinthan, Naif Abdullah Al-Dhabi, Savarimuthu Ignacimuthu, Ki Choon Choi, Jong-Hoon Kim,