Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation

Article ID	Journal	Published Year	Pages	File Type
5827595	European Journal of Pharmacology	2014	11 Pages	PDF

Abstract

Reproducible asthma-related outcomes and amenability to pharmacological intervention by mechanisms relevant to asthma demonstrate that an A. alternata induced pulmonary inflammation in BN rats is a valuable preclinical pharmacodynamic in vivo model for evaluating the pharmacological inhibitors of allergic pulmonary inflammation.

Keywords

PBS Th2 TSLP MIP-1α IL-25 IL-5 ILC2 CRTH2 IL-18 PAR-2 Alternaria alternata IL-6 IL-4 PGD2 MCP-1 OVA IL-1 β Ovalbumin interleukin-4 Interleukin-5 Interleukin-25 Interleukin-18 interleukin-6 interleukin-1 β Brown Norway regulated on activation, normal T cell expressed and secreted BAL fluid Phosphate buffered saline Thymic stromal lymphopoietin Bronchoalveolar lavage fluid RANTES Brown Norway rat chemoattractant receptor-homologous molecule expressed on Th2 cells Afa Monocyte chemotactic protein-1 Prostaglandin D2 protease-activated receptor 2

Related Topics

Life Sciences Neuroscience Cellular and Molecular Neuroscience

Preview

Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation

Authors

Malgorzata A. Gil, Michael Caniga, Janice D. Woodhouse, Joseph Eckman, Hyun-Hee Lee, Michael Salmon, John Naber, Valerie T. Hamilton, Raquel S. Sevilla, Kimberly Bettano, Joel Klappenbach, Lily Moy, Craig C. Correll, Francois G. Gervais,