Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5827876 | European Journal of Pharmacology | 2014 | 7 Pages |
Abstract
Single dose treatment reduced MI size by ~46% at 48Â h and 44% at three weeks. Double dosing evidenced a synergistic, 82% reduction at 3 weeks. EPI plus DOX also inhibited mitochondrial swelling in a synergic manner thus, possibly accounting for the cardioprotective effects whereas limited efficacy was observed with the other flavonoids. Given the apparent lack of toxicity in humans, the combination of EPI and DOX may have clinical potential for the treatment of myocardial IR injury.
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Authors
Pilar Ortiz-Vilchis, Katrina Go Yamazaki, Ivan Rubio-Gayosso, Israel Ramirez-Sanchez, Claudia Calzada, Diego Romero-Perez, Alicia Ortiz, Eduardo Meaney, Pam Taub, Francisco Villarreal, Guillermo Ceballos,