Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5827877 | European Journal of Pharmacology | 2014 | 8 Pages |
Abstract
Brief summary: We sought to investigate the effect of ALA to ameliorate cardiac hypertrophy and to further clarify the intrinsic molecular mechanisms. The results showed that ALA significantly inhibits cardiac hypertrophy induced by Ang II (in vitro) or pressure over-load (in vivo). ALA effectively suppressed the upregulation of PARP-2 and thereby promotes SIRT1 activation, leading to the inhibition of hypertrophic responses.97
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Authors
Lan Zhang, Jian Zou, Erqing Chai, Yongmei Qi, Yingmei Zhang,