| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5827993 | European Journal of Pharmacology | 2014 | 8 Pages |
Abstract
MAHMA/NONOate leads to a rapid and transient activation of platelet inhibitory systems, accompanied by decreased platelet aggregation induced by low dose agonists. At low MAHMA/NONOate concentrations, the effects are cGMP dependent and at higher concentrations additionally cGMP independent. The substance could be of interest for clinical situations requiring transient and subtotal inhibition of platelet function.
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Authors
Anna Kobsar, Sandra Simonis, Erdwine Klinker, Angela Koessler, Sabine Kuhn, Markus Boeck, Juergen Koessler,